# Resources

### An introduction to joint modelling of longitudinal and survival data

This post gives a gentle introduction to the joint longitudinal-survival model framework, and covers how to estimate them using our merlin command in Stata. A joint model consists of a continuous, repeatedly measured (longitudinal) outcome, and a time-to-event, with the two models linked by random effects, or functions of them. Let’s formally define everything we need. For […]

### Joint frailty models for recurrent and terminal events

In this post we’re going to take a look at joint frailty models, and how to fit them with our merlin command. Importantly, we’ll also discuss how to interpret the results. Joint frailty models An area of intense research in recent years is in the field of joint frailty models, which has become the commonly used name for […]

### Simulation, modelling and prediction with a non-linear covariate effect in survival analysis

Let’s begin. There will be a single continuous covariate, representing age, with a non-linear effect influencing survival. We’ll simulate survival times under a data-generating model that incorporates a non-linear effect of age. We’ll then fit some models accounting for the non-linear effect of age, and finally make predictions for specified values of age. Sounds simple, […]

### Defining a transition matrix for multi-state modelling

In this post we’ll take a look at how to define a custom transition matrix for use with our multistate package in Stata. The transition matrix A transition matrix governs the movement of a process between possible states. Within multi-state survival analysis, and particularly, the implementation of multi-state models in Stata, the transition matrix contains the most […]

### multistate v4.4.0: semi-parametric multi-state modelling

The headlines: predictms now supports the Cox model as a transition model, estimated using merlin or stmerlin Predictions from a multi-state Cox model are implemented using a simulation approach Supported predictions from a multi-state Cox model include transition probabilities, probability, and length of stay, los Let’s take a look at what we can now do with multistate and in particular, the predictms command. We’ll […]

### Simulating survival data with a continuous time-varying covariate…the right way

In this post we’ll take a look at how to simulate survival data with a continuous, time-varying covariate. The aim is to simulate from a data-generating mechanism appropriate for evaluating a joint longitudinal-survival model. We’ll use the survsim command to simulate the survival times, and the merlin command to fit the corresponding true model. Let’s assume a proportional hazards […]
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