New publication in Blood Cancer Journal
At a glance
A large, prospective, population-based study from Iceland investigating whether SARS-CoV-2 vaccination affects M-protein trajectories in over 1,800 individuals with MGUS or smouldering multiple myeloma.
This large, prospective population-based study from Iceland investigated whether SARS-CoV-2 vaccination affects M-protein trajectories in over 1,800 individuals with MGUS or smouldering multiple myeloma (SMM). Using linear mixed-effects models with patient-specific trajectories, flexible spline-based age modelling, and standardised marginal comparisons, the study found that annual increases in M-protein levels were small and similar before and after vaccination — across sexes, isotypes, vaccine types, and dose numbers.
These findings provide reassurance that SARS-CoV-2 vaccines do not adversely affect M-protein dynamics in individuals with MGUS and SMM.