Statistical tools
When a single hazard ratio misleads
A Cox model reports one hazard ratio. But if the treatment effect is delayed, wanes, or the curves cross, that single number hides the story. Pick a non-proportional scenario and see what a Cox model would report — against what actually happens to survival, RMST and the hazard ratio over time.
Red Door Analytics
Designing and analysing trials beyond proportional hazards
RMST, milestone survival, weighted log-rank, and flexible-parametric models with time-dependent effects — choosing and pre-specifying the right estimand is what merlin and our trial-design work are for.
See also: Survival DGM explorer· Multi-state explorer· Sample-size & power calculator· how we pre-specify an analysis →
The reported hazard ratio is a Cox model fitted to a simulated trial of the chosen mechanism; HR(t), RMST and survival are computed from the model. For teaching and estimand illustration.